Clinical Studies

In a study published in the Journal of Drugs and Dermatology, 93 patients were followed for 6 months after a single treatment. Three independent, blinded assessors (2 facial plastic surgeons and 1 dermatologic surgeon) rated improvement over baseline for each time frame. Average rating of the 3 assessors indicated greater than 25% improvement in depth and number of wrinkles and improvement in tightness of skin.* [1]

After one month, 9 out of 10 patients experienced a significant response and ~90% of those patients maintained that response 6 months after their first and only treatment!

“Our research clearly demonstrates the power of the Pellevé Wrinkle Reduction System. With a single Pellevé treatment, over 87% of our patients experienced an improvement in facial wrinkles at six months. The Pellevé Wrinkle Reduction System is an effective, non-invasive economical and safe tool”


Antonio Rusciani, M.D., Ph.D, Dermatologist & Plastic Surgeon

Division of Dermatology, Plastic & Reconstructive Surgery, Unv. of Rome, Italy[1]

[1] Rusciani A, Curinga G, Menichini G, Alfano C, Rusciani L. Nonsurgical tightening of skin laxity: a new radiofrequency approach. J Drugs Dermatol. 2007;6(4):381-386. Additional analysis of the raw data submitted in 510(k) K082834.

*via soft tissue coagulation

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